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. 2020 Jun 16;20:108. doi: 10.1186/s12911-020-01140-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The systematic pipeline of the proposed method. Step 1 is to collect data from different data sources. Step 2 is to pre-processing data, removing noisy data, rescaling data, normalizing data. Step 3 is to generate kernel matrices and then the kernel matrices are then combined in the Step 4. The number of dimensions is also optimised to obtain the most suitable numbers of dimensions and reduce the computation cost. The last step is to stratify patients using SVMs