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. 2020 Jun 15;20:241. doi: 10.1186/s12935-020-01327-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Circ_LDLR level was elevated in PTC tissues and cells. a Circ_LDLR was upregulated in PTC according to the analysis of GEO dataset GSE93522. b, c The expression level of circ_LDLR in PTC tissues (N = 60), cells and corresponding normal tissues and cells was determined using qRT-PCR (Student’s t-test). d, e The expression levels of circ_LDLR and LDLR were measured by qRT-PCR after treatment with or without RNase R in TPC-1 and SW579 cells. f, g The expression levels of circ_LDLR and LDLR were examined using qRT-PCR after treatment with Actinomycin D at indicated time points in TPC-1 and SW579 cells. *P < 0.05. Each bar represents mean ± SD