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. 2020 Jun 15;20:241. doi: 10.1186/s12935-020-01327-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Silencing of circ_LDLR inhibited PTC cell colony formation, proliferation, migration and invasion and induced cell apoptosis. TPC-1 and SW579 cells were transfected with si-NC or si-circ_LDLR. a The expression of circ_LDLR in TPC-1 and SW579 cells was examined using qRT-PCR. b The colony formation of TPC-1 and SW579 cells was assessed by colony formation assay. c, d The proliferation of TPC-1 and SW579 cells was evaluated using MTT assay. e The protein level of Ki67 in TPC-1 and SW579 cells was measured by western blot assay. f The apoptosis of TPC-1 and SW579 cells was analyzed by flow cytometry analysis. g, h The migration and invasion of TPC-1 and SW579 cells were evaluated by transwell assay. i, j The protein levels of Twist1 and E-cadherin in TPC-1 and SW579 cells were measured through western blot assay. *P < 0.05. Each bar represents mean ± SD