Fig. 3.

MiR-195-5p was a direct target of circ_LDLR in PTC cells. a MiR-195-5p was predicted to be a target of circ_LDLR. b The potential binding sequences between circ_LDLR and miR-195-5p were presented. c, d The luciferase activity in TPC-1 and SW579 cells co-transfected with circ_LDLR-wt or circ_LDLR-mut and miR-NC or miR-195-5p was measured by dual-luciferase reporter assay. e The expression of miR-195-5p in TPC-1 and SW579 cells transfected with si-NC or si-circ_LDLR was examined by qRT-PCR assay. f, g The expression of miR-195-5p in PTC cells and tissues (N = 60) was determined using qRT-PCR assay (Student’s t-test). h The correlation between circ_LDLR and miR-195-5p in PTC tissues was analyzed by Spearman’s correlation coefficient analysis. *P < 0.05. Each bar represents mean ± SD