Fig. 2.

Electron micrographs depicting the effect of chalcone derivatives on P. falciparum CQ resistant (RKL-9) strain. a untreated control “early ring stage (early trophozoite)” and b Untreated Control “Developing Schizont”; c, d artemisinin-treated; e, f compound 1-treated; g, h compound 2-treated; i, j compound 3-treated. a Arrow indicates appendages, b arrows represent appendages (a) and multiple nuclei (n). c–j Arrows show disintegrated forms of the malaria parasite, observed through darkly stained food vacuole c, d, f, i, larger vacuole formation (d–j), disintegrated and disoriented parasite membranes and organelles, ribosome loss along with condensed nuclei (c–j). The bar represents 800 nm–1 µm