Table 1.
IC50 value of chalcone derivatives and standard drugs [11]
| Drugs/compound name | Structure | Series name | MRC-2 (P. falciparum CQS strain) IC50 (µg/mL) | RKL-9 (P. falciparum CQR strain) IC50 (µg/mL) |
|---|---|---|---|---|
| (E)-1-(2,5-Dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one |  |
1 | O.13 | 0.14 |
| (E)-(3,4,5-Trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one |  |
2 | 0.35 | 0.19 |
| (E)-1-(3,4,5-Trimethoxyphenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one |  |
3 | 0.11 | 0.18 |
| CQ | – | NA | 0.17 | ND |
| Artemisinin (ng/mL) | – | NA | ND | 0.15 |
CQ chloroquine, CQS chloroquine sensitive, CQR chloroquine resistant, NA not applicable, ND not determine