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. 2020 Jun 16;18:67. doi: 10.1186/s12915-020-00791-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Loss of ACL/ACS or BCKDH alters the T. gondii gene expression. a Graph showing the number of RNA transcripts and proteins which are ≥ 2-fold up- (red) or downregulated (blue) in ΔACL/iΔACS parasites compared to RH (n = 3; limma p < 0.01). Statistical significance was determined as outlined in the ‘Material and methods’ section. b Venn diagram highlighting the overlap between differentially expressed RNA transcripts (Tra), proteins (Pro) and differentially acetylated proteins (Ace) which present a ≥ 2-fold change in ΔACL/iΔACS parasites compared to RH parasites (all p < 0.01). c Table highlighting genes which were found to be significantly up- (red background) and downregulated (blue background) at the transcriptome and proteome level in ΔACL/iΔACS parasites. d Graph highlighting the number of RNA transcripts and proteins which are ≥ 2-fold up- (red) or downregulated (blue) in ΔBCKDH parasites compared to RH (n = 3; limma p < 0.01). Statistical significance was determined as outlined in the ‘Material and methods’ section. e Venn diagram highlighting the overlap between differentially regulated acetylation sites (Ace), RNA transcripts (Tra) and proteins (Pro), which present a > 2-fold change (p < 0.01) in ΔBCKDH parasites compared to RH parasites. f Table highlighting genes which were found to be significantly up- (red background) and downregulated (blue background) at the transcriptome and proteome level in ΔBCKDH parasites. BCKDH, branched-chain α-keto acid dehydrogenase-complex; ACL, ATP citrate lyase; ACS, acetyl-CoA synthetase; RNA, ribonucleic acid