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. 2020 May 18;143(6):1780–1797. doi: 10.1093/brain/awaa110

Figure 3.

Figure 3

Evaluation of α-syn concentrations in plasma CNPase-positive extracellular vesicles isolated from patients with MSA, Parkinson’s disease, and healthy controls. CNPase-positive extracellular vesicles were isolated from human plasma using immunocapture; the α-syn concentrations in these extracellular vesicles (EV α-syn) and in the whole plasma (total α-syn) were measured using Luminex. (A) Extracellular vesicle α-syn; (B) total α-syn; (C) the extracellular vesicle/total α-syn ratio; and (D) the extracellular vesicle α-syn concentrations per vesicle (the extracellular vesicle α-syn concentrations/CNPase-positive extracellular vesicle concentrations). The boxes extend from the 25th to 75th percentiles. The middle dark lines indicate the medians. The whiskers extend to the minimum or the maximum values. *P < 0.05. CON = healthy control; EV = extracellular vesicle; PD = Parkinson disease.