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. 2020 Jun 5;143(6):1905–1919. doi: 10.1093/brain/awaa141

Figure 4.

Figure 4

Myelination-related protein levels in cuprizone diet-treated wild-type and TMEM106B-deficient mice. (A, C, E and G) Western blots show protein levels of CNP, MBP, and GAPDH in Tmem106b+/+ (wild-type, WT), Tmem106b+/− (heterozygous, Het), and Tmem106b−/− (KO) mice treated with normal diet (ND, A), 3 weeks of cuprizone diet (Cup 3W, C), 6 weeks of cuprizone diet (Cup 6W, E), and 6 weeks of cuprizone diet plus 6 weeks of normal diet (Rec 6W, G), respectively. (B, D, F and H) Quantification of the blots in A, C, E and G, respectively. Graphs represent the mean ± SEM. Data were analysed by Student’s t-test (n = 4). NS = not significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.