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. 2020 Jun 16;20:246. doi: 10.1186/s12935-020-01293-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Matrine inhibited growth, metastasis and activated autophagy of HCC cells in vitro. After Huh-7 and HCCLM3 cells were exposed to various concentrations of matrine for 48 h. a, b Cell viability was determined by CCK-8 assay. c Cell apoptosis rate was analyzed by Flow cytometry. d, e Western blot assay was used to detect the expression of apoptosis-related proteins Bcl-2, Bax and cleaved-caspase 9. f, g Cell cycle was determined by Flow cytometry. h, i Cell migration and invasion were estimated by Transwell assay. j, k Western blot assay was employed to measure the levels of autophagy-related proteins LC3-II, LC3-I and Beclin 1. *P < 0.05