Table 3.
Overall and RER Subgroup Multivariate Cox Regression Analysis for Major Cardiac-Related Events*
| Parameter/Statistic | Overall (n = 1,728) | RER <1.00 (n = 319) | RER 1.00–1.04 (n = 218) | RER 1.05–1.09 (n = 256) | RER ≥1.10 (n = 935) |
|---|---|---|---|---|---|
| VE/Vco2 slope | |||||
| Chi square (residual chi square) | 228.9 | 28.7 | 28.6 | 29.1 | 143.6 |
| p Value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| Adjusted HR (adjusted 95% CI) | 1.041 (1.029–1.052) | 1.041 (1.014–1.069) | 1.048 (1.016–1.081) | 1.036 (1.010–1.063) | 1.044 (1.027–1.061) |
| Peak Vo2 | |||||
| Chi square (residual chi square) | (108.0) | (12.7) | (14.7) | (15.3) | (67.8) |
| p Value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| Adjusted HR (adjusted 95% CI) | 0.898 (0.868–0.928) | 0.929 (0.868–0.994) | 0.899 (0.820–0.985) | 0.874 (0.801–0.954) | 0.890 (0.847–0.936) |
| LVEF | |||||
| Chi square (residual chi square) | (94.1) | (27.9) | (15.5) | (2.2) | (52.2) |
| p Value | <0.001 | <0.001 | <0.001 | 0.140 | <0.001 |
| Adjusted HR (adjusted 95% CI) | 0.954 (0.940–0.968) | 0.927 (0.895–0.959) | 0.936 (0.895–0.985) | – | 0.955 (0.935–0.975) |
| Peak RER | |||||
| Chi square (residual chi square) | (1.9) | – | – | – | – |
| p Value | 0.172 | – | – | – | – |
| Adjusted HR (adjusted 95% CI) | – | – | – | – | – |
| Age | |||||
| Chi square (residual chi square) | (0.8) | (0.0) | 0.3 | (0.8) | (0.9) |
| p Value | 0.358 | 0.995 | 0.566 | 0.357 | 0.333 |
| Adjusted HR (adjusted 95% CI) | – | – | – | – | – |