Table 3.

Lists of cysteine and aspartic peptidases identified from different tick species [modified from (75)].

Tick species	Type of peptidases	Name of peptidase	Functional characterization	Tissue expression
Haemaphysalis longicornis	Serine proteases	HlSP, HlSP2, HlSP3	RNAi and recombinant enzymes	Midgut and midgut lumen
Haemaphysalis longicornis	Legumain	H1Lgm, H1Lgm2	RNAi and recombinant enzymes	Midgut
Ixodes ricinus	Cathepsin L	IrCL1	RNAi and native or recombinant enzymes	Midgut, salivary glands, ovaries, and Malpighian tubules
Rhipicephalus microplus	Cathepsin L	BmCL1	Native or recombinant enzymes	Midgut
Haemaphysalis longicornis	Cathepsin B	Longipain	RNAi and recombinant enzymes	Midgut
Ixodes ricinus	Cathepsin D	IrCD1	RNAi and native or recombinant enzymes	Midgut
Haemaphysalis longicornis	Cathepsin D	Longepsin	RNAi and recombinant enzymes	Midgut and salivary glands
Haemaphysalis longicornis	Leucine amidopeptidase	HlLAP	RNAi and recombinant enzymes	Midgut, salivary glands, ovaries, and epidermis
Ixodes ricinus	Legumain	IrAE	RNAi and native or recombinant enzymes	Midgut
Haemaphysalis longicornis	Cathepsin L	H1CPL-A	Recombinant enzymes	Midgut
Ixodes ricinus	Cathepsin C	IrCC	Native enzyme	Midgut, salivary glands, ovaries, and Malpighian tubules
Ixodes ricinus	Cathepsin B	IrCB1	Native enzyme	Midgut
Rhipicephalus microplus	Cathepsin D	BmAP	Native enzyme	Midgut