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. Author manuscript; available in PMC: 2020 Jun 16.
Published in final edited form as: Gastroenterology. 2017 Apr 5;153(1):205–218.e8. doi: 10.1053/j.gastro.2017.03.048

Figure 4. SPDEF promotes tumor quiescence.

Figure 4.

(A) Intestinal microadenomas were allowed to grow for 2 weeks, followed by a 4 weeks ON; 4 weeks OFF tetracycline treatment (Model 3). Intestinal tissues from control mice (Lgr5CreERT2; β-cateninexon3; Rosa26LSL-rtta-ires-EGFP) or SPDEF mice (Lgr5CreERT2; β-cateninexon3; Rosa26LSL-rtta-ires-EGFP; TRE-Spdef) were collected at different time points followed by H&E staining. Quantitated result was shown. Each dot represents 1 mm length of intestinal epithelium randomly selected from jejunum. Wilcoxin test, Error bars, S.E.M., ***, p<0.001. Scale bars: 100 μm. (B) Immunofluorescent staining was performed by an anti-GFP and an anti-CD44v6 antibody. Scale bars: 100 μm.