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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Leukemia. 2019 Aug 19;34(1):210–223. doi: 10.1038/s41375-019-0540-7

Figure 5. Increased frequency of CD28+ and Tetramer+ CTL, Th1-type cytokine production, and proliferation of CD8+ T cells by PLGA/BCMA peptide-CTL.

Figure 5.

Figure 5.

Figure 5.

A: Increased frequency of CD28+ (Top Panel) and BCMA-specific Tetramer+ CD8 T cells with CD28 upregulation (Bottom Panel) in PLGA/BCMA peptide-CTL. B: Increased proliferation (CD8+ T cells gated) of PLGA/peptide-CTL in response to heteroclitic BCMA72-80 peptide in a time-dependent manner (Day 5 > Day 4 > Day 3). C: Increased frequency of peptide-specific IFN-γ+ cells (CD8+ T cells gated) in PLGA/BCMA-CTL in response to heteroclitic BCMA72-80 peptide.