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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Leukemia. 2019 Aug 19;34(1):210–223. doi: 10.1038/s41375-019-0540-7

Figure 6. Increased memory cells with functional immune activities against myeloma cells in PLGA/BCMA peptide-CTL.

Figure 6.

Figure 6.

Figure 6.

A: Increased CD8+ T cell proliferation in the PLGA/BCMA-CTL in response to HLA-A2+ U266 MM cells (Day 6 > Day 4). B: Increased induction of total CD45RO+ memory CTL by PLGA/BCMA peptide than by free peptide, measured post-3, post-4 and post-5 cycles of stimulation. C: Summary of three independent experiments (N=3) demonstrating increased memory CTL induction by PLGA/peptide than by free peptide, measured post-2 and post-4 cycles of stimulation. D: Increased level of central memory and effector memory CTL generation by stimulation with PLGA/peptide than free peptide, measured post-1 and post-3 cycles of stimulation. Increased maintenance of central memory cells was detected in BCMA-CTL generated by PLGA/peptide than free peptide, measured post-5 cycles of peptide stimulation.