Table 1 |.

Patient Characteristics of Primary and Secondary Gliosarcomas

Patient Characteristics	Total Gliosarcoma	Primary Gliosarcoma	Secondary Gliosarcoma	P-value
Baseline Demographics	32 patients	22 patients	10 patients
Median Age, years (range)	61.5 (33–77)	62 (33–77)	60.5 (39–70)
<50	25.0%	27.3%	20.0%	0.307
≥50–≤70	40.6%	31.8%	60.0%
<70	34.4%	40.9%	20.0%
Median KPS (range)	80% (60–100%)	80% (60–90%)	80% (70–100%)	-
RTOG RPA Class				0.559
III	-	-	-
IV	76.9%	85.7%	66.7%
V/VI	23.1%	14.3%	33.3%
Gender				0.703
Male	65.6%	68.2%	60%
Female	34.4%	31.8%	40%
Ethnicity				1.000
Caucasian	85.7%	83.3%	90%
Hispanic	14.3%	16.7%	10%
African-American	-	-	-
Asian	-	-	-
Tumor Characteristics
Neuroanatomic Localization				0.045
Multilobar	33.3%	40.5%	10.0%
Temporal	23.3%	30.0%	10.0%
Frontal	26.7%	10.0%	60.0%
Parietal	10.0%	10.0%	10.0%
Occipital	6.7%	5.0%	10.0%
Meningeal	3.1%	4.5%	0.0%
Laterality
Unilateral	90.6%	100.0%	70.0%	0.024
Bilateral	9.4%	-	30.0%
Treatment Characteristics
Surgical Extent of Resection
Gross total resection	56.7%	63.6%	30.0%
Near-total resection/Subtotal resection	43.3%	27.3%	70.0%
Biopsy	-	-	-
Adjuvant Radiotherapy
Yes	84.4%	77.3%	100.0%*
No	15.6%	22.7%	-
Median RT Dose, Gy (IQR)	60 (40.5–60)	59.4 (40.5–60)	60 (45–60)
Temozolomide
Yes	65.6%	63.6%	70.0%*
No	34.4%	36.4%	30.0%
Salvage Treatments
Reresection	41.9%	47.6%	30.0%
Stereotactic radiosurgery	3.1%	4.5%	0.0%
Systemic therapy	37.5%	36.4%	40.0%
Re-RT/Immunotherapy	6.3%	4.5%	10.0%

^*Refers to treatment following initial diagnosis of high-grade glioma prior to developing secondary gliosarcoma.