Table 3 |.
Univariate and Multivariate Cox Regression
| Factors | Univariate Analysis Overall Survival | Multivariate Analysis Overall Survival | ||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | |
| Histopathology | 0.271 | 0.012 | ||
| Gliosarcoma | 1.280 (0.825–1.988) | 3.267 (1.291–8.264) | ||
| GBM | Reference | Reference | ||
| Demographics | ||||
| Age at Diagnosis | 1.029 (1.021–1.037) | 0.000 | 1.027 (1.016–1.038) | 0.000 |
| KPS (Karnofsky Performance Status) | 0.966 (0.958–0.973) | 0.000 | 0.975 (0.965–0.986) | 0.000 |
| RTOG RPA Class | 0.000 | 0.899 | ||
| III | Reference | Reference | ||
| IV | 1.650 (1.162–2.345) | 1.090 (0.697–1.705) | ||
| V/VI | 4.542 (3.096–6.662) | 1.045 (0.583–1.872) | ||
| Gender | 0.555 | |||
| Female | Reference | |||
| Male | 1.060 (0.873–1.287) | |||
| Ethnicity | 0.538 | |||
| Caucasian | Reference | |||
| Hispanic | 1.027 (0.775–1.361) | |||
| African-American | 0.969 (0.609–1.453) | |||
| Asian | 0.656 (0.368–1.169) | |||
| Treatment Characteristics | ||||
| Surgical EoR | 0.000 | 0.000 | ||
| Biopsy | Reference | Reference | ||
| STR/NTR | 0.393 (0.297–0.518) | 0.372 (0.262–0.528) | ||
| GTR | 0.231 (0.159–0.338) | 0.229 (0.142–0.368) | ||
| Adjuvant Radiotherapy | 0.017 | 0.035 | ||
| No | Reference | Reference | ||
| Yes | 0.616 (0.426–0.919) | 0.206 (0.047–0.894) | ||
| RT Dose | 0.000 | 0.042 | ||
| 59.4–60 Gy | Reference | Reference | ||
| <59.4 Gy | 2.753 (2.093–3.621) | 1.396 (1.013–1.925) | ||
| Temozolomide | 0.000 | 0.000 | ||
| Yes | 0.643 (0.530–0.781) | 0.531 (0.420–0.672) | ||
| No | Reference | Reference | ||
| Reresection | 0.000 | 0.136 | ||
| Yes | 0.570 (0.459–0.708) | 0.819 (0.630–1.065) | ||
| No | Reference | Reference | ||