Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Contour plots of the required total sample size with the hazard ratios of time-to-events
of virologic and regimen failures, and correlation for the three copulas. The sample size
was calculated to detect the joint reduction for both time-to-event outcomes with the
overall power of 0.90 at the one-sided significance level of 0.0125, where
and 0.8;
and
;
, and
;
.
