Table 1.
Invasive and noninvasive hemodynamic data of different RV diastolic function profiles.
| Reference | Mild/Moderate | Severe | |||
|---|---|---|---|---|---|
| NRVEDP/NRAP (n = 68) | NRVEDP/HRAP (n = 10) | HRVEDP/NRAP (n = 27) | HRVEDP/HRAP (n = 69) | p | |
| Echocardiography | |||||
| ≥Moderate tricuspid regurgitationa | 8(12%) | 1(10%) | 4(15%) | 25(37%) | 0.003 |
| ≥Moderate pulmonary regurgitationa | 39(59%) | 5(50%) | 15(60%) | 40(60%) | 0.857 |
| ≥Moderate RV enlargementa | 43(63%) | 5(50%) | 20(74%) | 58(87%) | 0.005 |
| ≥Moderate RV systolic dysfunctiona | 13(19%) | 5(50%) | 5(19%) | 34(52%) | <0.001 |
| RVSP, mmHg | 56 ± 22 | 657 ± 32 | 69 ± 28 | 68 ± 23 | 0.098 |
| Tricuspid regurgitation velocity, m/s | 3.5 ± 0.8 | 3.8 ± 0.7 | 3.7 ± 1.0 | 3.7 ± 0.8 | 0.366 |
| Assumed RA pressure, mmHg | 8 ± 3 | 10 ± 3 | 11 ± 4 | 13 ± 2 | 0.006 |
| Pulmonary valve peak velocity, m/s | 2.7 ± 0.9 | 3.1 ± 0.9 | 3.0 ± 1.1 | 2.8 ± 1.0 | 0.552 |
| RA volume index, ml/m2 | 38 ± 11 | 54 ± 15 | 57 ± 16 | 73 ± 231 | 0.012 |
| ≥Moderate RA enlargementa | 31(46%) | 6(60%) | 19 (70%) | 49(71%) | 0.019 |
| LA volume index, ml/m2 | 22 ± 8 | 32 ± 7 | 26 ± 13 | 34 ± 13 | 0.008 |
| ≥Moderate LA enlargementa | 3(7%) | 2(29%) | 6(24%) | 19 (37%) | 0.004 |
| Medial E/e’ | 10 ± 5 | 11 ± 3 | 11 ± 4 | 11 ± 5 | 0.197 |
| Lateral E/e’ | 6 ± 4 | 9±3 | 6±2 | 7±3 | 0.062 |
| LV ejection fraction, % | 56 ± 10 | 59 ± 7 | 60 ± 7 | 56 ± 9 | 0.231 |
| Catheterization | |||||
| RA pressure, mmHg | 7±2 | 12 ± 1 | 8±2 | 16 ± 4 | <0.001 |
| RVEDP, mmHg | 10(8–12) | 13 (12–14) | 16(15–17) | 17(16–22) | <0.001 |
| RV systolic pressure, mmHg | 54(43–64) | 68(60–89) | 70(60–94) | 69(65–93) | <0.001 |
| PA systolic pressure, mmHg | 33(26–43) | 42(29–42) | 43(33–62) | 48(40–63) | <0.001 |
| PA diastolic pressure, mmHg | 7(6–10) | 14(9–18) | 8(6–15) | 14(11–18) | <0.001 |
| Mean PA pressure, mmHg | 18(14–23) | 23(20–33) | 24(17–33) | 28(23–33) | <0.001 |
| PAWP, mmHg | 11 ± 4 | 14 ± 3 | 12 ± 4 | 17 ± 5 | <0.001 |
| PVR, index, WU*m2 | 3.2(21.8–4.2) | 4.3(2.5–9.4) | 4.4(3.0–7.1) | 5.7(2.9–8.8) | <0.001 |
| Cardiac index, L/min*m2 | 2.5 ± 0.7 | 2.1 ± 0.5 | 2.1 ± 0.6 | 2.0 ± 0.5 | <0.001 |
| Mean arterial pressure, mmHg | 84 ± 14 | 91 ± 12 | 89 ± 15 | 87 ± 15 | 0.089 |
| Mixed venous saturation, % | 72 ± 6 | 69 ± 8 | 71 ± 7 | 65 ± 10 | <0.001 |
| Aortic saturation, % | 97(95–99) | 97(94–99) | 97(93–99) | 95(92–98) | 0.004 |
RV: right ventricle; LV: left ventricle; RA: Right atrium; LA: Left atrium; RVSP: right ventricular systolic pressure; E: mitral inflow early velocity; e’: tissue Doppler early velocity; RVEDP: right ventricular end-diastolic pressure; LV: left ventricle; PA: pulmonary artery; PAWP: pulmonary artery wedge pressure; PVR: pulmonary vascular resistance. Data were presented as mean ± standard deviation, median (interquartile range) or number (%).
a
Qualitative echocardiographic assessment.