Table 3:

Stepwise Forward Regression analysis for Learning and Memory: Statisitcs for variables contributing significantly to the model.

	Standardised Beta weight	Variance explained (%)	Cumulative variance explained (%)
Learning
Years of Education	.550 (p<.001)	21.2%	21.2%
Right Hippocampal Volume	.458 (p=.001)	20.2%	41.4%
Model Statistics	F=13.05, p<.001
(For reference and comparison to the Memory model below only: Grp X IL-6, Standardised Beta weight = −.232, p=.070)
Memory
Years of Education	.501 (p<.001)	21.4%	21.4%
Right Hippocampal Volume	.439 (p=.001)	17.1%	38.5%
Grp X IL-6	−.264 (=.043)	6.7%	45.2%
Model Statistics	F=9.92, p<.001

Variables entered into stepwise regression as independent variables: age, FSRP, BMI, Highest Education Level, Gender, GDS, HA1c, IL-1β, TNF-α, IL-6, left and right hippocampal volumes, group by cytokine interaction terms (Grp × IL-1β, Grp × TNF-α, Grp × IL-6).

GDS=Geriatric Depression Scale; FSRP=Framingham Stroke Risk Profile score; IL-6=interleukin 6