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. 2020 Jun 16;15(6):e0234731. doi: 10.1371/journal.pone.0234731

Fig 1. Schematic diagram of Alternaria induced chronic rhinosinusitis mouse model.

Fig 1

Intraperitoneal injection of ovalbumin (OVA) then intranasal instillation of Alternaria for 8 or 16 weeks was designed as an allergic CRS model. Intraperitoneal injections of phosphate buffered saline (PBS) then intranasal instillation of Alternaria for 8 or 16 weeks were designed as non-allergic CRS model. Intraperitoneal injection of PBS then intranasal instillation of PBS for 8 or 16 weeks was designed as negative control mice.