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Key reactions in the biosynthesis of eicosanoids by 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2). Arachidonic acid (AA) is the common substrate for the synthesis of PGs (COX-2 pathway) and LTs (5-LOX pathway). In the 5-LOX/COX-2 crossover pathway, both enzymes act sequentially to synthesize HKE2 and HKD2 as final products.
