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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Mol Nutr Food Res. 2020 May 4;64(11):e2000129. doi: 10.1002/mnfr.202000129

Figure 4.

Figure 4.

Dose-dependent effect of Uro-A, IsoUro-A, and Uro-C on COX-2 and 5-LOX product formation in stimulated human leukocytes. PGE2 (A), 5-HETE (B), and LTB4 (C) were quantified using LC-MS/MS analysis after AMPP derivatization. The effect of Uro-C on PGE2 as well as Uro-A and IsoUro-A on 5-HETE and LTB4 were included as controls. The box plots show the range of data between the 25th and 75th percentiles. Veh., vehicle. Solid horizontal line within bars: median. Dash horizontal line: mean. from 6 volunteers (n = 6). Each treatment was analyzed in duplicate. *p<0.05, **p<0.01, ***p<0.001 compared to the stimulated/veh.-treated group.