Table 3.
Common System Organ Class (SOC)a from CVAR and FAERS.
| Herb | SOC | FAERS |
CVAR |
||
|---|---|---|---|---|---|
| PRR | CI | PRR | CI | ||
| Avena sativa (Oats) | Skin and subcutaneous tissue disorders | 9.32 | 3.67-23.67 | 3.87 | 3.63-4.12 |
| Cannabis sativa (Marijuana) | Psychiatric disorders | 4.77 | 4.47-5.09 | 5.17 | 4.87-5.48 |
| Social circumstances | 8.2 | 7.37-9.12 | 7.96 | 6.11-10.36 | |
| Digitalis purpurea (Foxglove) | Cardiac disorders | 8.5 | 3.3-21.93 | 4.72 | 3.4-6.56 |
| Humulus lupulus (Hops) | Psychiatric disorders | 6.53 | 3.59-11.89 | 3.66 | 2.42-5.53 |
| Hypericum perforatum (St John’s Wort) | Psychiatric disorders | 4.21 | 3.64-4.86 | 3.43 | 2.74-4.29 |
| Paullinia cupana (Guarana) | Cardiac disorders | 3.54 | 1.99-6.31 | 4.72 | 3.52-6.32 |
| Peumus boldus (Boldo) | Investigations | 8.56 | 3.44-21.28 | 4.12 | 2.69-6.31 |
| Phleum pretense (Timothy-grass) | Immune system disorders | 13.27 | 8.03-21.92 | 12.47 | 7.91-19.66 |
| Silybum marianum (Milk thistle) | Hepatobiliary disorders | 3.45 | 2.95-4.04 | 4.57 | 2.94-7.12 |
| Taraxacum officinale (Dandelion) | Hepatobiliary disorders | 3.67 | 2.02-6.67 | 5.03 | 2.79-9.08 |
| Valeriana officinalis (Valerian) | Psychiatric disorders | 3.31 | 2.18-5.02 | 3.29 | 2.48-4.36 |
CI: confidence interval; CVAR: Canada Vigilance Adverse Reaction; FAERS: FDA’s Adverse Event Reporting System; PRR: Proportional Reporting Ratio; SOC: System Organ Class. Timeframe: FAERS:2004-2016 and CVAR: 1965-2017.
a
Not all data represent 100% adverse events; PRR scores are provided alongwith confidence intervals. ROR scores are available in Supplementary Tables.