Table 1.
Co-occurring sgRNAs Identified in Tumor Subclones
| Tumor 1 | Tumor 2 | Tumor 3 | Tumor 4 | Tumor 5 | Tumor 6 | |
|---|---|---|---|---|---|---|
| Subclone 1 | FUBP1, PTEN | PTEN, KDM5C | FUBP1, PTEN | PTEN, ARID1B | SMAD4, PTEN | NF2, SMARCB1, GATA3, RB1 |
| Subclone 2 | PTEN, NF2 | MLLT4, ACVR1B | PTEN, PIK3R1, TP53 | PTEN, RASA1 | PTEN, CDKN2A | SMAD4, PTEN |
| Subclone 3 | FUBP1, TP53, CDH1 | ZNF318, NF2 | PTEN, NCOR1 | STAG2, SMARCB1, PTEN | PIK3R1, NF2 | WT1, GATA3, RUNX1 |
| Subclone 4 | ATM,SMAD4 | GATA3, CDKN1A | RB, PTEN, FUBP1 | KDM5C | BAP1, RASA1, TRIP12 | SMAD2, TRIP12, ZNF318 |
| Subclone 5 | NF2, PIK3R1 | APC, RNP43 | RNX1, MLLT4 | KDM6A, ZNF318 | HLA-B, RBM10 | NF2, TGFBP2 |
| Subclone 6 | CDKN2A1, TGFBR2, DMK5C | CRIPAK, ASXL1, AJUBA | TRIP12, ZNF318 | FBXW7, TP53, PTEN | SMARCA4, ARHGAP35 | |
| Subclone 7 | CREBBP, STK11, SMAD4 | FUBP, KDM5C, PTEN | PIK3R1, MLLT4, NCOR1 | ARID2, RB1 |