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. 2020 Jun 12;13:5467–5478. doi: 10.2147/OTT.S236514

Figure 1.

Figure 1

miR-423 is upregulated in human breast cancer and correlates with poor prognosis. (A) Analysis of miR-423 expressions in TCGA BRCA cohort data. (B) Analysis of miR-423 expressions between human breast cancer tissues and matched adjacent non-tumor tissues in TCGA BRCA cohort data (number of pairs = 104). (C) Analysis of miR-423 expression in different clinical stages of TCGA BRCA cohort data. The boundaries of the boxes represent the lower and upper quartiles, the lines within the boxes and whiskers denote the median and outer limits. (D) Analysis of miR-423 expression in different N (node metastasis) and M (distant metastasis) classifications of TCGA BRCA cohort data. The boundaries of the boxes represent the lower and upper quartiles, the lines within the boxes and whiskers denote the median and outer limits. (E) Real-time PCR analysis of miR-423 expression in breast cancer cell lines and normal breast epithelial cells (NBECs). Transcript levels were normalized to U6 expression. (F) Kaplan–Meier analysis of the correlation between the miR-423 level and the overall survival (OS) of breast cancer patients in TCGA BRCA cohort. Bars represent the mean ± SD of three independent experiments; **P < 0.01, *P < 0.05.