Table 1. Comparison of CypI IC₅₀ against HCV replication or infection in different cell lines.

Replication (SGR)	IC50 (μM)
Cell line	CsA	CsA-like	Depsin	CsA-Prtc1
Huh7	0.188 ± 0.032	0.266 ± 0.037	0.043 ± 0.005	0.016 ± 0.002
Huh7.5	0.955 ± 0.123	1.374 ± 0.197	0.336 ± 0.053	0.055 ± 0.007
Huh7.5-CTRL	0.373 ± 0.085	0.527 ± 0.154	0.206 ± 0.043	0.070 ± 0.013
Huh7.5-RIG-I	0.560 ± 0.105	0.686 ± 0.181	0.243 ± 0.054	0.093 ± 0.019
Huh7.5-Mda5	0.754 ± 0.160	0.950 ± 0.247	0.302 ± 0.060	0.100 ± 0.018
Huh7.5-RIG-I/Mda5	0.820 ± 0.206	1.234 ± 0.298	0.351 ± 0.085	0.101 ± 0.021
Huh7 NT c7	0.068 ± 0.008	0.184 ± 0.026	0.037 ± 0.004	0.009 ± 0.001
Huh7 MAVS KO	0.112 ± 0.019	0.160 ± 0.023	0.056 ± 0.008	0.010 ± 0.001
Huh7 MAVS KO + C508R	0.075 ± 0.014	0.141 ± 0.028	0.045 ± 0.006	0.008 ± 0.001
Huh7 PKR KO c1	0.176 ± 0.034	0.971 ± 0.186	0.125 ± 0.021	0.021 ± 0.003
Huh7 PKR KO c4	0.172 ± 0.040	1.249 ± 0.327	0.091 ± 0.015	0.028 ± 0.004
Huh7 IRF1 KO c10	0.183 ± 0.042	1.219 ± 0.224	0.170 ± 0.039	0.027 ± 0.005
Huh7 IRF1 KO c11	0.193 ± 0.047	1.593 ± 0.284	0.192 ± 0.045	0.040 ± 0.006
Huh7 + DMSO	0.216 ± 0.050
Huh7 + C16	0.553 ± 0.098
Huh7.5 + DMSO	0.879 ± 0.131
Huh7.5 + C16	1.750 ± 0.495
HCVcc infection	IC50 (μM)
Cell line	CsA	CsA-like	Depsin	CsA-Prtc1
Huh7	0.043 ± 0.012	0.091 ± 0.020	0.096 ± 0.016	0.003 ± 0.001
Huh7.5	0.182 ± 0.037	0.316 ± 0.083	1.084 ± 0.373	0.014 ± 0.003
Huh7 NT c7	0.033 ± 0.005	0.123 ± 0.023	0.018 ± 0.003	0.012 ± 0.002
Huh7 PKR KO c4	0.095 ± 0.019	0.433 ± 0.101	0.051 ± 0.011	0.023 ± 0.005