Table II.
Pediatric asthma burden during the COVID-19 pandemic
| Pediatric asthma burden | Overall cohort | COVID-19 burden (deaths/million) |
P | Clinical setting |
P | ||||
|---|---|---|---|---|---|---|---|---|---|
| <10 | 10-100 | >100 | Primary | Secondary | Tertiary | ||||
| No. of participants contributing data, N | 61 | 22 | 10 | 23 | 13 | 9 | 34 | ||
| Asthma control: What percentage of your pediatric asthma patients are currently | |||||||||
| Well controlled | 70 (60-80) | 80 (70-90) | 70 (60-85) | 60 (50-80) | <.01 | 80 (80-90) | 70 (65-80) | 70 (60-80) | |
| Partially controlled | 20 (10-30) | 20 (10-20) | 20 (15-30) | 20 (20-30) | 20 (10-20) | 20 (20-35) | 20 (10-30) | ||
| Uncontrolled | 10 (0-10) | 10 (0-10) | 10 (0-10) | 10 (10-20) | 0 (0-10) | 10 (10-15) | 10 (10-13) | ||
| Asthma control: How does the current control of your patients compare with your expectations for these patients? | |||||||||
| Better than expected | 20 (10-40) | 30 (10-50) | 20 (10-25) | 20 (10-40) | 35 (20-43) | 25 (10-48) | 20 (10-30) | ||
| As expected | 85 (70-100) | 90 (65-100) | 80 (70-95) | 80 (70-100) | 90 (65-100) | 90 (75-100) | 80 (70-100) | ||
| Worse than expected | 10 (8-13) | 10 (0-10) | 10 (10-10) | 10 (10-20) | 0 (0-8) | 10 (3-18) | 10 (10-20) | .03 | |
| Risk ratio of better vs worse asthma control, RR (99% CI) | 2.69 (2.17-3.34) | 5.19 (3.06-8.81) | 2.90 (1.89-4.47) | 1.99 (1.50-2.64) | 12.67 (5.29-30.32) | 4.00 (1.30-12.33) | 2.07 (1.65-2.61) | ||
| What proportion of your patients required a change in their asthma treatments? | |||||||||
| Treatment escalation | 10 (10-30) | 10 (10-30) | 10 (10-20) | 20 (10-25) | 10 (10-30) | 15 (10-30) | 10 (10-30) | ||
| Unchanged treatment | 80 (60-90) | 80 (60-90) | 80 (80-85) | 80 (60-90) | 90 (70-90) | 80 (65-90) | 80 (60-90) | ||
| Treatment de-escalation | 10 (0-20) | 10 (0-20) | 10 (0-10) | 10 (0-20) | 10 (0-10) | 10 (5-15) | 10 (0-20) | ||
| Risk ratio escalation vs deescalation, RR (99% CI) | 1.41 (1.21-1.65) | 1.78 (1.27-2.50) | 5.21 (3.15-8.60) | 0.95 (0.79-1.16) | 2.22 (1.52-3.25) | 2.42 (1.05-5.55) | 1.24 (1.04-1.47) | ||
| Have you observed changes in the adherence to controller medications? | |||||||||
| Increased adherence | 20 (10-43) | 20 (10-30) | 25 (13-38) | 30 (10-50) | 30 (20-45) | 10 (8-15) | 20 (10-50) | ||
| Unchanged adherence | 80 (60-100) | 90 (70-100) | 80 (60-100) | 70 (53-100) | 70 (65-95) | 100 (95-100) | 80 (50-100) | .03 | |
| Reduced adherence | 10 (0-10) | 10 (0-10) | 10 (5-10) | 10 (0-30) | 10 (3-10) | 0 (0-3%) | 0 (0-18%) | ||
| Risk ratio of increased vs reduced adherence, RR (99% CI) | 1.97 (1.66-2.33) | 3.00 (2.01-4.47) | 3.79 (2.41-5.98) | 1.43 (1.16-1.77) | 3.11 (2.08-4.64) | 6.00 (0.38-94.23) | 1.73 (1.43-2.09) | ||
| Limited availability/access to asthma medications, n (%) | 21/69 (30) | 8/25 (32) | 2/15 (33) | 9/25 (36) | 6/15 (40) | 3/11 (28) | 12/42 (29) | ||
Values are median (IQR) unless otherwise indicated.