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Substrate binding cleft of SARS-CoV-2 Mpro harboring the docked inhibitors. Top three docked inhibitors. (A) Tipranavir, (B) Lopinavir–Ritonavir, and (C) Raltegravir occupy the active site region with independent confirmation as the originally (D) bound α-ketoamide 13b ligand in the co-crystallized structure (PDB ID: 6Y2F).
