Table 2.

Brain regions involved in conceptual fear learning (CS+ > CS−) with greater activation in the PTSD group than the trauma-exposed control group.

Sub/cortical region	Number voxels 3.8 mm3	Max Z statistic	Peak 3D coordinates
			x	y	z
Rostral cingulate/vmPFC right	389	4.05	42	60	57
Putamen left	194	3.43	56	73	38
Planum temporale right	191	3.59	17	56	39
Frontal pole right	161	3.45	40	89	32
Posterior cingulate cortex left	148	3.33	48	40	50
Lingual gyrus/precuneus right	144	4.6	36	34	36
Postcentral right	144	3.33	31	47	67
Putamen right	140	3.68	29	59	34
Central operculum right	79	3.7	20	60	46
Precuneus left	51	3.47	58	35	41
Lateral occipital cortex left	41	3.01	68	24	47
Amygdala right	43	3.42	35	62	22
Intracalcarine cortex right	39	3.29	37	21	39
Right postcentral	39	3.26	28	52	57
Supramarginal right	35	3.04	21	51	64
Dorsal ACC left	30	3.51	49	89	47
Subgenual ACC right	24	3.61	41	71	31
Precentral right	162	3.43	44	49	68
Temporo-occipital fusiform left	23	3.17	65	33	37
Cuneus right	22	3.08	39	21	51
Amygdala right	21	3.81	30	62	29

All clusters are significant at p < 0.05 with whole-brain correction using FLAME 2.

vmPFC ventromedial prefrontal cortex, ACC anterior cingulate cortex.