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. 2020 Jun 17;5:78. doi: 10.1038/s41392-020-0181-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — UCHL3 is upregulated and associated with poor survival in NSCLC. a Western blot analysis showed increased UCHL3 protein expression in 20 paired lung cancer (ADC and SCC) tissue samples relative to adjacent normal lung tissue samples. b TCGA analysis of UCHL3 mRNA expression in ADC (Normal n = 58; Tumor n = 488) and SCC (Normal n = 50; Tumor n = 409) lung cancer samples compared to normal lung samples. Each dot represents a sample. Data are shown as the mean ± SD; ****p < 0.0001. c IHC analysis showed increased UCHL3 expression levels in lung cancer (magnification, ×100 scale bar = 200 μm; magnification, ×200 scale bar = 100 μm; magnification, ×400 scale bar = 50 μm). d IHC scores indicating UCHL3 expression levels in lung cancer tissues versus normal tissues (Normal n = 8; SCC n = 10; ADC n = 10). Data are shown as the mean ± SD; **p < 0.01. e Kaplan–Meier curves showing overall survival rates associated with UCHL3 expression in lung cancer. NSCLC p = 0.0002; ADC p = 0.0157; SCC p = 0.6641; tested by log-rank test. Two-tailed Student’s t-test (b) or one-way ANOVA with multiple comparisons (d)