Table 1.
General Characteristics of the Patients.
| Training Group | Validation Group | Pseudo-progression | p-value | |
|---|---|---|---|---|
| Total number of patients | 37 | 20 | 5 | |
| Males/ females | 24/ 13 | 14/ 6 | 4/ 1 | 0.7746 |
| Age (years) | 55 ± 12 | 60 ± 9 | 55 ± 9 | 0.2860 |
| Tumour location | 0.7807 | |||
| Eloquent | 8 | 4 | 0 | |
| Near eloquent | 14 | 9 | 3 | |
| Non eloquent | 15 | 7 | 2 | |
| Midline shift (mm) | 3.8 ± 3.8 | 3.3 ± 3.1 | 2.9 ± 3.6 | 0.8358 |
| Pre-OP tumour size (mL)a | 44 ± 25 | 39 ± 26 | 40 ± 14 | 0.7573 |
| GTR/ STRa | 29/ 8 | 13/ 7 | 5/ 0 | 0.2228 |
| PFS (median, days) | 262 | 181 | 778 | 0.0104 |
| OS (median, days) | 523 | 407 | 864 | 0.0144 |
| MGMT un-methylated | 16 | 4 | 1 | 0.0958 |
| methylated | 10 | 9 | 3 | |
| IDH-1 wild type | 34 | 17 | 4 | > 0.9999 |
| mutated | 3 | 1 | 1 |
aThe pre-operative tumour volume and the extent of resection were evaluated based on the contrast enhanced T1-weighted MRI.
GTR = gross total resection; STR = subtotal resection; PFS (progression free survival); OS = overall survival; MGMT = O6-methylguanine DNA methyltransferase; IDH-1 = Isocitrate dehydrogenase.