Table 1.
Associations between MMP9 protein expression and clinicopathological features in the whole Cohort
| Parameters | MMP9 cytoplasmic (C+) expression | MMP9 stromal (S+) expression | ||||
|---|---|---|---|---|---|---|
| Negative/low expression n (%) | High expression n (%) |
p value (χ2) | Negative/low expression n (%) | High expression n (%) |
p value (χ2) | |
| Age at diagnosis (years) | ||||||
| < 50 | 172 (70.5) | 72 (29.5) |
0.740 (0.110) |
143 (58.0) | 101 (42.0) |
0.019 (5.543) |
| ≥ 50 | 309 (71.7) | 122 (28.3) | 212 (49.0) | 219 (51.0) | ||
| Histological grade | ||||||
| 1 | 76 (84.0) | 14 (16.0) |
< 0.0001 (20.570) |
61 (68.0) | 29 (32.0) |
< 0.0001 (27.165) |
| 2 | 177 (78.0) | 51 (22.0) | 141 (62.0) | 87 (38.0) | ||
| 3 | 225 (64.0) | 125 (36.0) | 153 (44.0) | 197 (56.0) | ||
| Stage | ||||||
| I | 303 (74.0) | 105 (26.0) |
0.081 (6.743) |
226 (55.0) | 182 (46.0) |
0.012 (11.005) |
| II | 138 (67.0) | 69 (33.0) | 106 (51.0) | 101 (19.0) | ||
| III | 37 (70.0) | 16 30.0) | 23 (43.0) | 30 (57.0) | ||
| Tumour size | ||||||
| < 2.0 cm | 234 (74.0) | 81 (26.0) |
0.137 (2.206) |
170 (54.0) | 145 (46.0) |
0.604 (1.269) |
| ≥ 2.0 cm | 246 (69.0) | 110 (31.0) | 185 (52.0) | 171 (48.0) | ||
| Histological type | ||||||
| Ductal including NST* | 406 (69.2) | 181 (30.8) |
0.003 (11.586) |
300 (51.1) | 287 (48.9) |
0.092 (4.88) |
| Lobular | 48 (87.0) | 7 (13.0) | 34 (62.0) | 21 (38.0) | ||
| Special type | 22 (88.0) | 3 (12.0) | 17 (68.0) | 8 (32.0) | ||
| IHC subtypes | ||||||
| ER+/HER2-low proliferation | 115 (81.0) | 26 (19.0) |
0.002 (14.857) |
85 (60.3) | 56 (40.0) |
0.001 (15.879) |
| ER+/HER2− high proliferation | 154 (72.0) | 60 (28.0) | 126 (59.0) | 88 (41.0) | ||
| Triple negative | 80 (64.0) | 45 (36.0) | 51 (40.0) | 74 (60.0) | ||
| HER2 + | 63 (62.0) | 39 (38.2) | 48 (47.0) | 54 (53.0) | ||
| Nottingham Prognostic Index | ||||||
| GPG | 155 (84.0) | 29 (16.0) |
< 0.0001 (20.523) |
117 (63.0) | 67 (37.0) |
0.002 (12.257) |
| MPG | 253 (68.0) | 122 (32.0) | 187 (49.0) | 188 (51.0) | ||
| PPG | 72 (64.0) | 40 (36.0) | 51 (46.0) | 61 (56.0) | ||
| Lymphovascular invasion (LVI) | ||||||
| Negative/probable | 230 (73.0) | 86 (27.0) |
0.445 (0.584) |
180 (57.0) | 136 (43.0) |
0.031 (4.669) |
| Definite | 157 (70.0) | 68 (30.0) | 107 (48.0) | 118 (52.0) | ||
Significant p values are highlighted in bold; GPG; Good Prognostic Group; MPG: Moderate Prognostic Group; PPG: Poor Prognostic Group
* Medullary like carcinoma was renamed as Ductal NST carcinoma according to the recent WHO book 2019 and added to the ductal NST group