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Animal body weight (g, average ± SEM). a Acute toxicity study of conjugate 1 with doses of 3.125, 6.25, 12.5 and 25 mg/kg Dau content. b Acute toxicity study of conjugate 2 with doses of 3.125, 6.25, 12.5 and 25 mg/kg Dau content. c Chronic toxicity study of NGR-Dau conjugates 1 and 2 with dose of 10 mg/kg Dau content, 5 treatments: marked by black arrows. 3 mice per group
