Table 1.
In vitro antiproliferative activity of NGR-Dau conjugates and Dau on KS, HT-29 and MRC-5 cells after 24 h treatment followed by 48 h incubation in drug free medium and 72 h continuous treatment. All IC50 values represent average ± SD
| KS (24 h) IC50 (μM) |
KS (72 h) IC50 (μM) |
HT-29 (24 h) IC50 (μM) |
HT-29 (72 h) IC50 (μM) |
MRC-5 (72 h) IC50 (μM) |
|
|---|---|---|---|---|---|
| Dau | 0.1 ± 0.01 | 0.07 ± 0,01 | 0.09 ± 0.01 | 0.1 ± 0.01 | 0.25 ± 0.06 |
| 1 | 22.7 ± 2.3 | 15.2 ± 0.3 | 32.4 ± 1.4 | 29.3 ± 1.0 | > 100 |
| 2 | 8.0 ± 0.8 | 4.3 ± 0.1 | 13.9 ± 1.6 | 7.2 ± 0.2 | 25.4 ± 3.5 |