Table 4.
Mean estimate ratios (MER)a obtained by zero-inflated negative binomial model of taxa abundances by grade and stage of breast cancer with adjustment for total counts, age and race/ethnicity (model 2, MER)
| Grade high (III) vs low (I/II) | Stage high (III) vs low (I/II) | |||||
|---|---|---|---|---|---|---|
| MER | p value | MER | p value | |||
| p__Actinobacteria | ||||||
| f__Coriobacteriaceae | g__ | .238 | 0.0028 | |||
| f__Coriobacteriaceae | g__Eggerthella | 9.365 | 0.0004 | |||
| p__Firmicutes | ||||||
| f__Clostridiaceae | g__ | 3.290 | .0011 | |||
| f__Clostridiaceae | g__Clostridium | 6.144 | 0.0088 | 5.986 | .0005 | |
| f__Lachnospiraceae | .343 | 0.0003 | ||||
| f__Lachnospiraceae | g__Anaerostipes | .116 | < 0.0001 | |||
| f__Ruminococcaceae | .488 | 0.0066 | ||||
| f__Veillonellaceae | g__Acidaminococcus | .0098 | .0003 | |||
| f__Veillonellaceae | g__Veillonella | 9.794 | 0.0025 | 15.12 | < .0001 | |
| f__Erysipelotrichaceae | g__Catenibacterium | .151 | .0002 | |||
| p__Proteobacteria | ||||||
| f__Enterobacteriaceae | 6.389 | .0024 | ||||
| f__Pasteurellaceae | g_Haemophilus | 71.633 | < .0001 | |||
aMER > 1 means higher taxa in high grade (III) than low grade (I and II) and in high stage (III) than low stage (I and II); low grade and low stage was the respective reference group