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. 2020 May 2;45(7):1711–1728. doi: 10.1007/s11064-020-03019-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A subgroup of cellular mRNA transcripts are selectively incorporated into neuronal EVs. mRNA was extracted from iPSC-derived neurons (n = 3) and EVs (n = 2), followed by RNA Seq and bioinformatics as described. a Abundance of specific mRNA transcripts was compared in neurons and EVs (red line at mean, green line shows linear regression), followed by b rank comparison for the 500 most abundant mRNA transcripts in EVs (green line shows linear regression, dotted line shows 95% confidence) and c comparison of the top 30 most enriched mRNA transcripts in EVs against their rank abundance in neurons. d Volcano plot of all mRNA transcripts. Blue dotted line indicates the log₂ fold change analysis threshold (log₂ fold change > 1) and orange dotted line denotes the –log₁₀ (p value) threshold (-log₁₀ (p) > 2). n number refers to an independent induction of iPSCs to neurons, from each a sEV preparation was isolated (Color figure online)