Table 1.
Top 30 most enriched genes in EVs and rank expression in neurons
| Gene | Neuron rank | EV enrichment rank | mRNA length (bases) |
|---|---|---|---|
| CCDC9 | 148 | 1 | 2027 |
| KCNE3 | 3011 | 2 | 3143 |
| RASSF3 | 3983 | 3 | 3507 |
| ABCA4 | 4897 | 4 | 7328 |
| SLC14A2 | 4804 | 5 | 4073 |
| TNFSF4 | 3222 | 6 | 3492 |
| SVEP1 | 2104 | 7 | 12,205 |
| CTXN1 | 4524 | 8 | 1237 |
| SNAI2 | 2352 | 9 | 2180 |
| CYLC2 | 4922 | 10 | 2149 |
| SEC14L3 | 5011 | 11 | 2086 |
| SLC6A2 | 3138 | 12 | 2471 |
| MX2 | 5120 | 13 | 3408 |
| ANP32B | 224 | 14 | 1483 |
| KNG1 | 5209 | 15 | 4198 |
| TNN | 5040 | 16 | 5042 |
| PRPH | 1912 | 17 | 1800 |
| ITIH5 | 4734 | 18 | 6716 |
| PLEKHA4 | 434 | 19 | 3073 |
| CLDN11 | 5196 | 20 | 2169 |
| KIF1C | 474 | 21 | 7917 |
| CHIT1 | 4595 | 22 | 2248 |
| CPNE9 | 4179 | 23 | 2042 |
| C6orf141 | 1475 | 24 | 1450 |
| PAQR7 | 3633 | 25 | 3297 |
| SCLY | 3142 | 26 | 2526 |
| TRDN | 3354 | 27 | 1294 |
| FBF1 | 2437 | 28 | 3626 |
| GALNT6 | 4745 | 29 | 5307 |
| CENPP | 5064 | 30 | 2570 |
Using RNA seq data, ratios of mRNA abundance were calculated (EV: neuron) and those mRNA transcripts with the highest enrichment were tabulated and compared to their rank abundance in neurons