TABLE 1.

Compounds targeting mitochondria in the treatment of cancer.

Compound	Cancer type	Effect	References
Mdivi-1	Lung cancer	Inhibitor of Drp1 and proapoptotic effects	Rehman et al., 2012
Piperlongumine	Ovarian cancer	Activate Drp1 and induce both fission and apoptosis	Farrand et al., 2013
Lectin	Ovarian cancer	Activate AKT signal pathways and de-phosphorylates Drp1	Chowdhury et al., 2017
DHE	Lung cancer	Induce mitochondrial dysfunction, mitophagy and apoptosis	Chang et al., 2016
Nanomicelle	Non-small cell lung carcinoma	Trigger excessive mitophagy/autophagy and energy depletion	Zhu et al., 2020
CerS1/C18 pyridinium ceramide	Hypopharyngeal cancer	Target autophagosomes to mitochondria and induce lethal mitophagy	Sentelle et al., 2012
AT 101	Glioma	Induce mitochondrial dysfunction and mitophagy	Meyer et al., 2018
Sodium selenite	Glioma	Induce mitochondrial damage and subsequent mitophagy	Kim et al., 2007
LCL-461	Acute myeloid leukemia	Induce lethal mitophagy	Dany et al., 2016
Liensinine	Breast cancer	Sensitize cancer cells to chemotherapy through DNM1L-mediated mitofission	Zhou et al., 2015
Isoliensinine	Breast cancer	Induce cancer cell apoptosis through ROS and p38 MAPK/JNK activation	Zhang et al., 2015
Mito-CP	Colon cancer	Induce changes in mitochondrial bioenergetics, block mTOR-mediated proliferation and induce mitophagy	Boyle et al., 2018
Mito-Metformin
Abrus agglutinin	Glioblastoma	Trigger ceramide production, induce ER stress and ROS to promote mitophagy	Panda et al., 2018
BAY 87-2243	Melanoma	Inhibit mitochondrial complex I, trigger mitophagy	Basit et al., 2017
B5G1	Liver cancer	Inhibit PINK1-Parkin dependent mitophagy	Yao et al., 2019