TABLE 1.
Compound | Cancer type | Effect | References |
Mdivi-1 | Lung cancer | Inhibitor of Drp1 and proapoptotic effects | Rehman et al., 2012 |
Piperlongumine | Ovarian cancer | Activate Drp1 and induce both fission and apoptosis | Farrand et al., 2013 |
Lectin | Ovarian cancer | Activate AKT signal pathways and de-phosphorylates Drp1 | Chowdhury et al., 2017 |
DHE | Lung cancer | Induce mitochondrial dysfunction, mitophagy and apoptosis | Chang et al., 2016 |
Nanomicelle | Non-small cell lung carcinoma | Trigger excessive mitophagy/autophagy and energy depletion | Zhu et al., 2020 |
CerS1/C18 pyridinium ceramide | Hypopharyngeal cancer | Target autophagosomes to mitochondria and induce lethal mitophagy | Sentelle et al., 2012 |
AT 101 | Glioma | Induce mitochondrial dysfunction and mitophagy | Meyer et al., 2018 |
Sodium selenite | Glioma | Induce mitochondrial damage and subsequent mitophagy | Kim et al., 2007 |
LCL-461 | Acute myeloid leukemia | Induce lethal mitophagy | Dany et al., 2016 |
Liensinine | Breast cancer | Sensitize cancer cells to chemotherapy through DNM1L-mediated mitofission | Zhou et al., 2015 |
Isoliensinine | Breast cancer | Induce cancer cell apoptosis through ROS and p38 MAPK/JNK activation | Zhang et al., 2015 |
Mito-CP | Colon cancer | Induce changes in mitochondrial bioenergetics, block mTOR-mediated proliferation and induce mitophagy | Boyle et al., 2018 |
Mito-Metformin | |||
Abrus agglutinin | Glioblastoma | Trigger ceramide production, induce ER stress and ROS to promote mitophagy | Panda et al., 2018 |
BAY 87-2243 | Melanoma | Inhibit mitochondrial complex I, trigger mitophagy | Basit et al., 2017 |
B5G1 | Liver cancer | Inhibit PINK1-Parkin dependent mitophagy | Yao et al., 2019 |