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A working model proposed for the V2-mediated nucleocytoplasmic trafficking of the V1 protein. Viral genomic DNAs are bound by V1 and import into the nucleus with the help of KAP α1 via the specific interaction between V1 and V2, leading the formation of a V2-V1-ssDNA complex. With the help of exportin-α, V2 facilitates the V1-ssDNA complex to exit the nucleus to the perinucleus and the cytoplasm.
