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. 2020 Jun 10;11:1046. doi: 10.3389/fmicb.2020.01046

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Copyright © 2020 Riaz, Kaur, Shwayat, Behboudi, Kishore and Pathan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PAF C-16 structural analogs on the growth of intracellular M. smegmatis. M. smegmatis infected THP-1 cells were treated for 24 h with either solvent control (10 μl ethanol/ml), Lyso-PAF (A), 2-O-methyl PAF (B), PAF C-18 (C) or Hexanolamino PAF (D) at indicated concentrations, before lysis and plating. The data is expressed in terms of percentage, where solvent control is considered as 100% survival. The data shown as box plots represent median, interquartile and minimal and maximal values for four individual experiments performed in triplicates. Statistically significant differences between tests samples (PAF analogs) versus solvent controls were determined using Kruskal–Wallis test and any two data sets were compared using post hoc Dunn’s multiple comparison (**p ≤ 0.01 and *p ≤ 0.05).