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. 2020 Jun 10;11:1046. doi: 10.3389/fmicb.2020.01046

FIGURE 4.

FIGURE 4

Effect of PAFR antagonists (ABT-491 and WEB-2086) on PAF C-16 induced growth inhibition of intracellular M. smegmatis. M. smegmatis infected THP-1 samples were treated for 24 h with either solvent control (10 μl ethanol/ml), ABT-491 (2 μg/ml), PAF C-16 (1 μg/ml) and a combination of ABT-491 (2 μg/ml) and PAF C-16 (1 μg/ml) (Test-1) (A), or WEB-2086 (2 μg/ml) and a combination of WEB-2086 (2 μg/ml) and PAF C-16 (1 μg/ml) (Test-2) (B), before lysis and plating. The data is expressed in terms of percentage, where solvent control is taken as 100% survival and different treated conditions are compared to it. The data shown as box plots represent median, interquartile and minimal and maximal values for four individual experiments performed in triplicates. Statistically significant (*p = 0.02) differences were found in the case of both PAFR antagonists with PAF C-16 alone treated samples using Mann–Whitney test.