FIGURE 4.

LIR-mediated interaction with ATG8 proteins. The complex between LC3B and p62 [PDB entry: 2ZJD (Ichimura et al., 2008)] is reported as an example. LC3B mediates protein-protein interactions and recruits the autophagy receptors through the binding of a short linear motif, called LIR. The complex of LC3B (gray cartoon and surface) with the LIR motif of mammalian p62 (orange cartoon) is shown. The key residues for the binding of p62 LIR motif to LC3B are indicated as sticks. The two hydrophobic pockets (HP1 and HP2) and the R10 and R11 in the binding interface of LC3B are indicated in yellow and light blue, respectively.