TABLE 1.
List of known interactors of ATG8 proteins for which a LIR-dependent binding has been experimentally validated by mutagenesis.
| Protein (UniProt recommended name, short name if available) | UniProt ID | LIR type | LIR core sequence | References (PMID) |
| Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) | Q9C0C7 | W-type | 1049-WDQL-1052 | 25215947 30217973 |
| Ankyrin-2 | Q01484 | W-type | 1592-WVIV-1595 | 29867141 |
| Ankyrin-3 | Q12955 | W-type | 1989-WIEF-1992 | 29867141 |
| AP-2 complex subunit alpha-1 (AP2A1) | O95782 | W-type | 879-WKQL-882 | 24067654 |
| Ataxin-3 | P54252 | F-type W-type |
74-FFSI-77 130-WFNL-133 |
31625269 |
| Atlastin-3 | Q6DD88 | F-type | 390-FKQL-393 | 30773365 |
| Autophagy-related protein 2A (ATG2A) | Q2TAZ0 | F-type | 1362-FCIL-1365 | 32009292 |
| Autophagy-related protein 2B (ATG2B) | Q96BY7 | F-type | 1491-FCIL-1494 | 32009292 |
| Autophagy-related protein 13 (ATG13) | O75143 | F-type | 444-FVMI-447 | 23043107 |
| Bcl-2-like protein 13 (Bcl2-L-13) | Q9BXK5 | W-type | 276-WQQI-279 | 26146385 |
| BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) | Q12983 | W-type | 83-WVEL-86 | 23209295 22505714 |
| BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) | O60238 | W-type | 36-WVEL-39 | 20010802 28442745 |
| Beclin 1-associated autophagy-related key regulator (Barkor/ATG14) | Q6ZNE5 | W-type | 435-WENL-438 | 30767700 |
| Beclin1 | Q14457 | F-type | 97-FTLI-100 | 30767700 |
| C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) | Q9UQF2 | F-type | 336-FDCL-339 | 24914561 |
| Cadherin-6 | P55285 | Y-type | 764-YDYL-767 | 27375021 |
| Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) | Q13137 | non-canonical | 134-LVV-136 | 23022382 |
| Calreticulin | P27797 | W-type | 200-WDFL-203 | 30429217 |
| Catenin beta-1 | P35222 | W-type | 504-WPLI-507 | 23736261 |
| Cell cycle progression protein 1 (CCPG1) | Q9ULG6 | W-type | 14-WTVI-17 | 29290589 31006538 |
| Cryptochrome-1 (CRY1) | Q16526 | Y-type | 273-YKKV-276 287-YGQL-290 488-YQQL-491 494-YRGL-497 |
29937374 |
| Cysteine protease ATG4A (ATG4A) | Q8WYN0 | F-type | 393-FEIL-396 | 28287329 |
| Cysteine protease ATG4B (ATG4B) | Q9Y4P1 | F-type | 388-FEIL-391 | 28287329 |
| Cysteine protease ATG4C (ATG4C) | Q96DT6 | F-type | 455-FVLL-458 | 28287329 |
| Disrupted in schizophrenia 1 protein (DISC1) | Q9NRI5 | F-type | 210-FSFI-213 | 30488644 |
| E3 ubiquitin-protein ligase NEDD4 (NEDD4) | P46934 | W-type | 685-WEII-688 | 28470758 |
| Fas-apoptotic inhibitory molecule 2 (FAIM2) | Q9BWQ8 | W-type | 65-WAYV-68 | 31914609 |
| FUN14 domain-containing protein 1 (FUNDC1) | Q8IVP5 | Y-type | 18-YEVL-21 | 22267086 |
| FYVE and coiled-coil domain-containing protein 1 (FYCO1) | Q9BQS8 | F-type | 1280-FDII-1283 | 20100911 23043107 |
| Golgi reassembly stacking protein 2 (GRS2) | Q9H8Y8 | Y-type | 196-YGYL-199 | 29297744 |
| Hepatocyte growth factor receptor (HGF receptor) | P08581 | Y-type | 1234-YYSV-1237 | 30786811 |
| Histone acetyltransferase KAT2A (KAT2A) | Q92830 | Y-type | 734-YTTL-737 | 31878840 |
| Huntingtin | P42858 | W-type | 3035-WVML-338 | 25385587 |
| Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-A) | O15111 | W-type W-type |
651-WHLL-654 740-WSWL-743 |
29717061 |
| Junction-mediating and -regulatory protein (JMY) | Q8N9B5 | W-type | 13-WVAV-16 | 26223951 |
| Kelch repeat and BTB domain-containing protein 6 (KBTBD6) | Q86V97 | W-type | 668-WVRV-671 | 25684205 |
| Kelch repeat and BTB domain-containing protein 7 (KBTBD7) | Q8WVZ9 | W-type | 668-WVQV-671 | 25684205 |
| Mitochondrial antiviral-signaling protein (MAVS) | Q7Z434 | Y-type | 9-YKYI-12 | 27551434 28141795 |
| Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) | Q969V5 | Y-type | 327-YRAL-330 | 25224329 |
| Mitogen-activated protein kinase 15 (MAPK15) | Q8TD08 | Y-type | 340-YQMI-343 | 22948227 |
| Next to BRCA1 gene 1 protein (NBR1) | Q14596 | Y-type | 732-YIII-735 | 21620860 |
| NLR family member X1 (NLRX1) | Q86UT6 | F-type | 463-FQLL-466 | 30804553 |
| Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) | Q9UHK0 | W-type | 40-WAML-43 | 29700228 |
| Nuclear receptor corepressor 1 (N-CoR1) | O75376 | F-type | 346-FPEI-349 | 30952864 |
| Optineurin | Q96CV9 | F-type | 178-FVEI-181 | 25294927 23805866 |
| Paxillin | P49023 | Y-type | 40-YQEI-43 | 27184837 |
| Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) | Q14318 | F-type W-type |
24-FEVL-27 93-WLDI-96 |
28381481 31908024 |
| Pericentriolar material 1 protein (PCM-1/PCM1) | Q15154 | F-type | 1963-FVKV-1966 | 31053714 |
| Phosphatidylethanolamine-binding protein 1 (PEBP-1) | P30086 | W-type | 55-WDGL-58 | 27540684 |
| Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3K type 3) | Q8NEB9 | F-type | 250-FELV-253 | 30767700 |
| Pleckstrin homology domain-containing family M member 1 (PLEKHM1) | Q9Y4G2 | W-type | 635-WVNV-638 | 25498145 28655748 |
| Prohibitin-2 (PHB2) | Q99623 | Y-type | 121-YQRL-124 | 28017329 |
| Protein kinase C zeta type (PRKCZ) | Q05513 | F-type | 578-FEYI-581 | 31857374 |
| Protein PML (PML) | P29590 | Y-type F-type |
119-YRQI-122 612-FFDL-615 |
25419843 |
| RB1-inducible coiled-coil protein 1 (RBCC1) | Q8TDY2 | F-type | 702-FETI-705 | 23043107 |
| Receptor of activated protein C kinase 1 (RACK1) | P63244 | W-type W-type |
132-WNTL-125 170-WDKL-173 |
27129200 |
| Reticulon-3 (RTN3) | O95197 | F-type Y-type F-type W-type F-type Y-type |
205-FTLL-208 217-YSKV-220 248-FEVI-251 342-WDLV-345 555-FEEL-558 790-YDIL-793 |
28617241 |
| Reticulophagy regulator 1 (RETREG1) | Q9H6L5 | F-type | 455-FELL-458 | 26040720 |
| Segment polarity protein disheveled homolog DVL-2 (Disheveled-2/Dvl2) | O14641 | W-type | 444-WLKI-447 | 20639871 |
| Sequestosome-1 (SQSTM1) | Q13501 | W-type | 338-WTHL-341 | 17580304 18653543 19812211 27158844 |
| Serine/threonine-protein kinase 3 (STK3) | Q13188 | non-canonical | 365-MVI-367 | 31857374 |
| Serine/threonine-protein kinase Nek9 (NEK9) | Q8TD19 | W-type | 967-WCLL-970 | 31857374 |
| Serine/threonine-protein kinase ULK1 (ULK1) | O75385 | F-type | 357-FVMV-360 | 23043107 |
| Serine/threonine-protein kinase ULK2 (ULK2) | Q8IYT8 | F-type | 353-FVLV-356 | 23043107 |
| SHC-transforming protein 1 (SHC1) | P29353 | Y-type | 10-YNPL-13 | 30109811 |
| Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) | Q7Z698 | W-type Y-type |
378-WMAL-381 394-YLPL-397 |
27028858 |
| Starch-binding domain-containing protein 1 (STBD1) | O95210 | W-type | 203-WEMV-206 | 21893048 |
| Stimulator of interferon genes protein (hSTING) | Q86WV6 | Y-type Y-type Y-type |
167-YLRL-170 199-YILL-202 245-YELL-248 |
30568238 |
| Tax1-binding protein 1 (TAX1BP1) | Q86VP1 | W-type non-canonical |
49-WVGI-52 141-LVV-143 |
23209807 |
| TBC1 domain family member 25 (TBC1D25) | Q3MII6 | W-type | 136-WDII-139 | 21383079 |
| TBC1 domain family member 5 (TBC1D5) | Q92609 | W-type F-type |
59-WEEL-63 787-FTIV-790 |
22354992 |
| Tectonin beta-propeller repeat-containing protein 2 (TECPR2) | O15040 | W-type | 1408-WEVI-1411 | 26431026 |
| Testis-expressed protein 264 (TEX264) | Q9Y6I9 | F-type | 273-FEEL-276 | 31006538 |
| TNF receptor-associated factor 6 (TRAF6) | Q9Y4K3 | Y-type | 406-YISL-409 | 30806153 |
| Transcription factor E2F3 isoform d (E2F3d) | O00716 | Y-type | 160-YSRL-163 | 30740539 |
| Transitional endoplasmic reticulum ATPase (TER ATPase) | P55072 | Y-type F-type |
143-YRPI-146 163-FKVV-166 |
27561680 |
| Translocation protein SEC62 (SEC62) | Q99442 | F-type | 363-FEMI-366 | 27749824 |
| Tripartite motif-containing protein 5 (Trim5α) | Q0PF16 | W-type (C- to N-terminus orientation) | 193-ILDW-196 | 30282803 |
| Tumor protein p53-inducible nuclear protein 1 (TP53INP1) | Q96A56 | W-type | 31-WILV-34 | 22470510 |
| Tumor protein p53-inducible nuclear protein 2 (TP53INP2) | Q8IXH6 | W-type | 35-WLII-38 | 22470510 |
| Ubiquitin-like modifier-activating enzyme 5 (UBA5) | Q9GZZ9 | non-canonical | 341-WGIEL-345 | 26929408 30990354 |
| von Hippel-Lindau disease tutor suppressor (VHL) | P40337 | Y-type | 98-YPTL-101 | 30902965 |
| WD repeat and FYVE domain-containing protein 3 (Alfy) | Q8IZQ1 | F-type | 3346-FIFV-3349 | 24668264 |
| WD repeat-containing protein 81 (WDR81) | Q562E7 | W-type Y-type |
544-WIDL-547 578-YGVV-581 |
28404643 |
For each interactor, we provide the UniProt ID, the LIR type, the LIR core sequence and the PMID of the corresponding scientific publications.