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. 2020 Jun 10;11:1189. doi: 10.3389/fimmu.2020.01189

Figure 1.

Figure 1

Structure of HMGB1. (A) Detailed summary of various domains and motifs in HMGB1. (B) Signature L-loop structure of the A-box and B-box structures of HMGB1. (C) Overall structure of HMGB1 showing the functional A-box cysteines (C23 and C45) and their geometric distribution in HMGB1. A-box and B-box structures modified based on 2YRQ [Protein Data Bank (PDB) IP: 2yrq] using PyMol. NLS, nuclear localization sequence; NES, nuclear export signal; TLR4, toll-like receptor 4; RAGE, receptor for advanced glycation endproducts; Tim-3, T-cell immunoglobulin and mucin domain-containing protein-3; LPS, lipopolysaccharide; LTA, lipoteichoic acid; C1q, complement component 1q; IL-1β, interleukin 1β; CXCL12, C-X-C motif chemokine 12; F, phenylalanine; I, isoleucine; C, cysteine; C-term, C-terminal; N-term, N-terminal. Solid line; known binding domain or sequence of HMGB1, Dotted grey line; unknown sequence of HMGB1.