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. 2020 Jun 16;11:3067. doi: 10.1038/s41467-020-16918-x

Fig. 3. Liver HuR deficiency aggravates HFD-induced NAFLD.

Fig. 3

a HuR cKO and WT littermates were fed HFD for 4 weeks, whereupon body weight, liver weight, and ratio of liver/body weight were measured (WT, n = 6; cKO, n = 7). The food uptake was also measured (WT and cKO, n = 9). Data are the means ± SD (Blank columns, WT; Black columns, cKO). b Representative images of liver sections staining by using H&E and Oil Red O to evaluate the NAFLD phenotype in mice described in a (WT, n = 5; cKO, n = 5). c Livers of mice described in a were used for analyzing the levels of triglyceride (TG) and cholesterol (Chol) (WT, n = 5; cKO, n = 7). d Mouse livers described in a were used for analyzing the levels of ATP and the relative levels of mtDNA (WT, n = 6; cKO, n = 6). Data in c and d are the means ± SD; significance was analyzed by using two-tailed Mann–Whitney U test (*p < 0.05; **p < 0.01). All the error bars are equivalent throughout the figure. Source data are provided as a Source Data file.