Table 3.
EpiVax scores (Heavy and Light Chain), Fab Tm (DSC), mAb Tagg (DSF) values of all 10 variants including PCa75.
| Variants | HC mutations | LC mutation | EpiVax Score (Heavy Chain) | EpiVax Score (Light Chain) | Fab (Tm) °C | mAb (Tagg) °C | KD (SPR, pM) | ||
|---|---|---|---|---|---|---|---|---|---|
| 14 | 20 | 81 | 1 | ||||||
| PCa75 | R | P | H | A | 1.99 | −19.3 | 61.8 | 61.5 | 247.0 |
| PCa46 | P | L | Q | A | −44.3 | −19.3 | 68.3 | 70.5 | 279.2 |
| PCa47 | P | L | H | A | −8.9 | −19.3 | 68.1 | 70.2 | 284.5 |
| PCa50 | R | L | Q | A | −29.6 | −19.3 | 66.2 | 67.8 | 281.6 |
| PCa51 | R | L | H | A | 5.75 | −19.3 | 65.9 | 68 | 298.6 |
| PCa60 | R | L | Q | A | −29.6 | −33.6 | 69.7 | 72.3 | 323.9 |
| PCa62 | P | L | Q | D | −44.3 | −33.6 | 69.4 | 75.7 | 323.3 |
| PCa63 | P | L | H | D | −8.93 | −33.6 | 69.6 | 75.6 | 325.3 |
| PCa64 | P | P | Q | D | −37.3 | −33.6 | 68.2 | 70 | 372.3 |
| PCa65 | P | P | H | D | −2.02 | −33.6 | 68.5 | 70 | 405.8 |
| PCa66 | R | L | Q | D | −29.6 | −33.6 | 69.4 | 72.2 | 405.4 |