Table 7.
Candidate drug usage and the onset of glaucoma in Sichuan Provincial People’s Hospital in 136,128 electronic medical records (EMRs) from August 2015 to August 2018.
| Drug | Repetitions | Effect | Cases | Glaucoma Patients | Glaucoma Prevalence | Cases (age > 40) | Glaucoma Patients (age > 40) | Pa | ORb |
|---|---|---|---|---|---|---|---|---|---|
| Cytarabine | 6 | Anticancer, antimetabolism, antiviral, DNA polymerase inhibitor | 435 | 0 | 0 | 242 | 0 | 4.30E-03 | 0 |
| Caffeine | 6 | Doping (central), adenosine receptor antagonist, phosphodiesterase inhibitor | 3 | 0 | 0 | 0 | 0 | \ | \ |
| Dipyridamole | 6 | Vasodilators (coronary arteries), platelet aggregation inhibitors, phosphodiesterase inhibitors | 46 | 0 | 0 | 15 | 0 | 4.30E-03 | 0 |
| Paclitaxel | 5 | Antineoplastic, tubulin depolymerization inhibitor | 634 | 0 | 0 | 573 | 0 | 4.30E-03 | 0 |
| Dasatinib | 5 | Antineoplastic, tyrosine kinase inhibitors | 6 | 0 | 0 | 2 | 0 | 4.30E-03 | 0 |
| Celecoxib | 5 | Analgesic, anti-inflammatory, COX-2 inhibitors | 1719 | 1 | 5.82E-04 | 1488 | 1 | 1.74E-03 | 0.067 |
| Theophylline | 6 | Bronchodilator, phosphodiesterase inhibitor | 4594 | 5 | 1.09E-03 | 4397 | 5 | 7.60E-06 | 0.113 |
| Aspirin | 5 | Analgesic, anti-inflammatory, antipyretic, antirheumatic, antiplatelet, COX inhibitors | 5358 | 16 | 2.99E-03 | 5197 | 13 | 9.80E-04 | 0.248 |
| Nicardipine | 6 | Antihypertensive, vasodilators, calcium channel blockers | 588 | 2 | 3.40E-03 | 564 | 2 | 8.30E-02 | 0.35 |
We found 9 drugs used in this hospital. a, P values for each drug assuming we had 1000 participants who used the drugs and 1000 participants in the healthy population age > 40 when the investigated samples were less than 1000. b, OR: odds ratio.