Table 2.
Validation of previously published prognostic biomarkers for LIHC in OSlihc.
| Gene symbol | Biomarker name | Clinical survival terms | In OSlihc | In reference | Prognostic outcome (higher expression) | Ref. | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cut-off | p value | HR | 95%CI | Case | Cut-off | p value | case | Detection level | Validation | |||||
| SPP1 | Osteopontin (OPN) | OS | Upper 25% | 0 | 2.3521 | 1.6394-3.3747 | 361 | / | <0.05 | 110 | serum | Yes, serum biochemical assay | worse | (Yang et al., 2008; Jin et al., 2014; Qin, 2014) |
| DSS | 0.0126 | 1.8422 | 1.1403-2.9763 | / | ||||||||||
| DFI | 0.0183 | 1.5 | 1.071-2.1008 | DFS: p < 0.05 | ||||||||||
| PFI | 0.0078 | 1.5611 | 1.1242-2.1679 | / | ||||||||||
| BIRC5 | Survivin | OS | Upper 25% | 4e-04 | 1.9443 | 1.3457-2.8093 | 361 | upper n = 31/lower n = 41 | / | 72 | protein | Yes, IHC assay | worse | (Fields et al., 2004) |
| DSS | 2e-04 | 2.4062 | 1.5199-3.8095 | / | ||||||||||
| DFI | 9e-04 | 1.753 | 1.2585-2.4419 | DFS: 0.0098 | ||||||||||
| PFI | 0.0012 | 1.7165 | 1.2375-2.3809 | / | ||||||||||
| MKI67 | Ki-67 | OS | Upper 25% | 6e-04 | 1.9063 | 1.3174-2.7586 | 361 | upper n = 47/lower n = 0 | 0.0009 | 67 | protein (Ki-67 labeling index >10% indicated poor prognosis) | Yes, IHC assay | worse | (King et al., 1998) |
| DSS | 0.0011 | 2.1783 | 1.3664-3.4729 | / | ||||||||||
| DFI | 0.002 | 1.6821 | 1.2089-2.3404 | DFS: 0.02 | ||||||||||
| PFI | 0.0027 | 1.6475 | 1.1891-2.2827 | / | ||||||||||