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. 2020 Jun 10;8:455. doi: 10.3389/fcell.2020.00455

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Copyright © 2020 Branscome, Paul, Yin, El-Hage, Agbottah, Zadeh, Liotta and Kashanchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stem cell EV-mediated CNS repair in vivo. SCI results in the disruption of the blood spinal cord barrier. Upon injury, stem cell EVs can be administered via several different routes. Treatment with stem cell EVs is characterized by both functional and histological improvements. Figure adapted from Guo et al. (2019) and Riazifar et al. (2019).